Tanshinone IIA

Product Name  Tanshinone IIA
Synonyms  1,6,6-Trimethyl-6,7,8,9-tetrahydro-phenanthro[1,2-b]furan-10,11-dione
CAS  568-72-9
MF  C19H18O3
MW  294.34
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Description

Tanshinone IIA is a naturally occurring compound discovered in the roots of the Salvia miltiorrhiza plant, which is indigenous to China and other Asian countries. It is a diterpene quinone that has been investigated for possible health benefits such as cardiovascular health, inflammation, and cancer prevention.

Tanshinone IIA is well-known for its possible cardiovascular health benefits. It has been shown to improve lipid profiles, lower blood pressure, and have antiplatelet effects, all of which serve to lower the chance of cardiovascular disease.

Here are the main benefits and applications of Tanshinone IIA:

  1. Cardiovascular Health: Tanshinone IIA is most well-known for its cardiovascular benefits. It has been shown to improve blood circulation, reduce blood vessel inflammation, and prevent the formation of blood clots. This makes it potentially beneficial in treating conditions like coronary artery disease, ischemic heart disease, and hypertension.
  2. Anti-inflammatory and Antioxidant Properties: This compound exhibits significant anti-inflammatory and antioxidant activities, which can help in reducing oxidative stress and inflammation in the body. These properties are beneficial in treating chronic inflammatory diseases and in preventing cell damage.
  3. Anticancer Effects: Research has indicated that Tanshinone IIA may have potential anticancer effects. It has been observed to induce apoptosis (programmed cell death) in various cancer cells, inhibit cancer cell proliferation, and prevent metastasis.
  4. Neuroprotective Effects: There is emerging evidence suggesting that Tanshinone IIA may have neuroprotective properties, potentially beneficial in neurodegenerative diseases like Alzheimer’s and Parkinson’s disease. It may help in protecting nerve cells from damage and in improving cognitive functions.
  5. Liver Protection: Tanshinone IIA has shown hepatoprotective effects, meaning it can help in protecting the liver from damage caused by toxins, oxidative stress, and inflammation. This makes it potentially useful in treating liver diseases such as hepatitis and cirrhosis.
  6. Antimicrobial Activity: Some studies have found that Tanshinone IIA possesses antimicrobial properties against various bacteria and fungi, which could make it useful in treating infections.
  7. Skin Health: Due to its anti-inflammatory and antioxidant properties, Tanshinone IIA is also being explored for its potential benefits in treating skin conditions like acne, psoriasis, and aging-related skin damage.