Sildenafil

Product Name: Sildenafil, Sildenafil Citrate
CAS No: 139755-83-2; Citrate form: 171599-83-0
Trade Name: Viagra; Revatio
MF: C22H30N6O4S
MW: 474.6
Appearance: White powder
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Description

Sildenafil belongs to a class of drugs known as phosphodiesterase type 5 inhibitors. It is prescribed to treat erectile dysfunction (male impotence). It aids in achieving and maintaining a sufficient erection for sexual activity. When a man is sexually aroused, it allows more blood to flow into the penis. It only stimulates sexual desire and does not increase sexual desire. Sildenafil works by increasing blood flow to the penis during sexual stimulation to treat erectile dysfunction. An erection can result from increased blood flow. Sildenafil alleviates PAH by relaxing blood vessels in the lungs, allowing blood to flow freely.

  1. Materials/Composition: Sildenafil is a phosphodiesterase type 5 (PDE5) inhibitor. Chemically, it’s a pyrazolopyrimidinone derivative and is formulated as blue, film-coated rounded-diamond-shaped tablets.
  2. Main Benefit:
    • For Erectile Dysfunction: Sildenafil works by increasing blood flow to the penis, helping a man achieve and maintain an erection when sexually stimulated. It does not cause an erection without sexual arousal.
    • For Pulmonary Arterial Hypertension: It relaxes the blood vessels in the lungs, allowing blood to flow more easily, thereby reducing the workload of the heart.
  3. Application:
    • Erectile Dysfunction: It’s used on an as-needed basis, typically taken about an hour before sexual activity. However, it can be taken anywhere from 30 minutes to 4 hours before intercourse.
    • Pulmonary Arterial Hypertension: For PAH, it’s often taken three times a day, with or without food.
  4. Dosage:
    • The typical starting dose for ED is 50 mg, but depending on effectiveness and tolerance, this may be increased to a maximum recommended dose of 100 mg or decreased to 25 mg.
    • For PAH, the dosage may vary and should be followed as prescribed by a healthcare provider.

This medication may be available under several brand names and/or in various forms. This medication may not be available in all of the forms or be approved for all of the conditions discussed here. Furthermore, some forms of this medication may not be appropriate for all of the conditions listed here.

Sildenafil Citrate, as a drug ingredient, is effective in treating erectile dysfunction.

Foreal Biotech offers global customers high quality Sildenafil powder / Sildenafil Citrate powder. Please contact us directly if you have any inquiry.

 

Reference:

Sildenafil, sold under the brand name Viagra among others, is a medication used to treat erectile dysfunction and pulmonary arterial hypertension. It is unclear if it is effective for treating sexual dysfunction in women.

It is taken by mouth or injection into a vein. Onset is typically within 20 minutes and lasts for about 2 hours.

–Wikipedia

Sildenafil functions as a selective and competitive inhibitor of type 5 phosphodiesterases (PDE5) on smooth muscle cells in the penis and pulmonary vasculature, and is used extensively for erectile dysfunction and less commonly for pulmonary hypertension.

Sildenafil has been associated with rare instances of clinically apparent liver injury.

LiverTox