Reference Substances

Description

Sanguinarine is a benzophenanthridine alkaloid derived from the rhizomes of the plant Sanguinaria canadensis. Sanguinarine is an excellent DNA and RNA intercalator that only binds the iminium ion. Sanguinarine has been shown to have antibiotic, anti-apoptotic, anti-fungal, anti-inflammatory, and anti-angiogenic properties.

Sanguinarine is an alkaloid derived primarily from plants in the Papaveraceae family, like the bloodroot plant. It’s known for its distinctive red color and has been used in various applications, mainly in the field of dentistry and herbal medicine. Here are some key aspects of sanguinarine:

1. Antimicrobial Properties: Sanguinarine has potent antimicrobial properties, making it effective against a variety of microorganisms. It’s particularly known for its ability to inhibit the growth of bacteria and fungi, which is why it’s often used in dental hygiene products like toothpaste and mouthwash.
2. Anti-inflammatory Effects: It has been observed to have anti-inflammatory properties, which can be beneficial in reducing swelling and redness in various conditions.
3. Dental Applications: Due to its antimicrobial and anti-inflammatory effects, sanguinarine is commonly used in dental care products. It helps in preventing dental plaque formation, gingivitis, and periodontal diseases.
4. Cancer Research: Some studies suggest that sanguinarine might have anti-cancer properties. It has been researched for its potential to induce apoptosis (programmed cell death) in cancer cells, although this application is still largely in the experimental stage.
5. Herbal Medicine: Traditionally, sanguinarine has been used in herbal medicine for treating skin conditions and as a component in herbal remedies due to its antimicrobial and anti-inflammatory properties.
6. Safety and Side Effects: While sanguinarine can be beneficial, it’s important to use it cautiously. In high concentrations, it can be toxic and cause side effects like tissue damage. Therefore, it’s crucial to use sanguinarine-containing products as directed and consult healthcare professionals for advice, especially when used for medicinal purposes.