Description
Genistein is an isoflavone that functions as both an angiogenesis inhibitor and a phytoestrogen. In 1899, it was isolated from dyer’s broom, Genista tinctoria, thus the chemical name. In 1926, the compound composition was found to be identical to that of prunetol.
Genistein is a phytoestrogen and antineoplastic flavonoid derived from soy. Genistein binds to and inhibits protein-tyrosine kinase, disrupting signal transmission and causing cell differentiation. This drug also inhibits topoisomerase-II, resulting in DNA fragmentation and apoptosis while also halting the G2/M cell cycle. Genistein is antiangiogenic, antiviral, and anti-inflammatory.
