Enoxolone

Product Name: 18β-Glycyrrhetinic Acid (Enoxolone)
CAS No: 471-53-4
MF: C30H46O4
MW: 470.68
Appearance: White to off white crystalline powder
Assay: 98-102% Titr.
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Description

Enoxolone (INN, BAN; also known as glycyrrhetinic acid or glycyrrhetic acid) is a pentacyclic triterpenoid derivative of the beta-amyrin type obtained from the hydrolysis of glycyrrhizic acid, which was obtained from the herb liquorice. It is used in flavoring and it masks the bitter taste of drugs like aloe and quinine. It is effective in the treatment of peptic ulcer and also has expectorant (antitussive) properties. It has some additional pharmacological properties including antiviral, antifungal, antiprotozoal, and antibacterial activities.

Application: Enoxolone can be used in cosmetics and personal care products in the formulation of makeup, fragrance, skin care, shaving, personal hygiene and suntan products.

Main Uses:

  1. Medical Uses:
    • Anti-inflammatory Properties: Enoxolone is known for its anti-inflammatory effects. It’s used in treatments for conditions such as eczema and allergic reactions.
    • Gastrointestinal Treatments: It has been used to treat peptic ulcers due to its soothing properties on the gastrointestinal tract.
    • Antiviral Activity: There is some evidence suggesting that enoxolone may have antiviral properties, particularly against viruses like the herpes simplex virus.
  2. Skincare and Cosmetics:
    • Soothing Agent: In skincare, enoxolone is valued for its ability to soothe irritated skin. It’s a common ingredient in creams and lotions designed for sensitive or inflamed skin.
    • Anti-aging Properties: Some skincare products use enoxolone for its potential anti-aging benefits, as it may help in maintaining skin elasticity and reducing wrinkles.
  3. Research Applications:
    • Enoxolone is also a subject of research in various fields, including its potential use in cancer therapy and as a neuroprotective agent.