Description
Triptolide is derived from Tripterygium wilfordii celastraceae plants and is also known as tripterygium wilfordii lactone alcohol or tripterygium wilfordii lactone. It has anti-tumor, anti-inflammatory, and immunosuppressive properties due to the presence of three epoxy groups of diterpene lactone molecules. Triptolide inhibits tumor cell proliferation and induces apoptosis in tumor cell lines in vitro, and it decreases tumor size or growth in vivo. Furthermore, it makes tumor cells more susceptible to other therapeutic techniques, such as chemoradiation. TPL’s synergistic impacts with other chemotherapeutic agents were shown to be effective in preclinical animal models.
